Horsenettle can be difficult to control in peanuts.  We have limited data from North Carolina research.  Recommendations from other states show that Cadre/Impose, Ultra Blazer or Cobra provide Fair control, and that level of control occurs when weeds are small.  A combination of Cadre/Impose plus either Cobra or Ultra Blazer might provide Good control but only if herbicides are applied when this weed is small.